Construction glass and glazing (CGG) workers have high rates of work-related musculoskeletal disorders (WRMSDs). For this study, the researchers conducted interviews with CGG workers and worksite observations to identify problems leading to the higher rates of WRMSDs and to gather information about improvements that are needed to lower the risk for injury. CGG job tasks were classified in five categories, and ergonomic task-based estimates were done using the Posture, Activity, Tools, and Handling (PATH) method. The CGG workers’ level of risk of developing musculoskeletal injuries was scaled using the Rapid Entire Body Assessment (REBA) method. The results of this study provided a baseline database for future evaluations of ergonomic interventions to reduce CGG workers’ risk for injury.